Journal of critical care
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Journal of critical care · Oct 2018
Meta AnalysisNon-invasive ventilation in children and adults in low- and low-middle income countries: A systematic review and meta-analysis.
We systematically reviewed the effects of NIV for acute respiratory failure (ARF) in low- and low-middle income countries. ⋯ NIV for ARF in these settings appears to be effective.
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Journal of critical care · Oct 2018
Emergence of antimicrobial resistance to piperacillin/tazobactam or meropenem in the ICU: Intermittent versus continuous infusion. A retrospective cohort study.
Prolonged infusion of beta-lactam antibiotics is broadly recognized as a strategy to optimize antibiotic therapy by achieving a higher percentage of time that concentrations remain above the minimal inhibitory concentration (% fT>MIC), i.e. the pharmacokinetic/pharmacodynamic (PK/PD) index. However, %fT>MIC may not be the PK/PD index of choice for inhibition of resistance emergence and it is therefore unsure what impact prolonged infusion of beta-lactam antibiotics may have on the emergence of resistance. ⋯ In this retrospective cohort study, the emergence of antimicrobial resistance to piperacillin/tazobactam or meropenem was not related to the mode of infusion.
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Journal of critical care · Oct 2018
Editorial CommentSearching for better outcomes in septic shock trials.