Journal of critical care
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Journal of critical care · Aug 2021
Viral load dynamics in intubated patients with COVID-19 admitted to the intensive care unit.
Prolonged viral RNA detection in respiratory samples from patients with COVID-19 has been described, but the clinical relevance remains unclear. We studied the dynamics of SARS-CoV-2 on a group and individual level in intubated ICU patients. ⋯ In general SARS-CoV-2 RNA levels in respiratory samples in patients with severe COVID-19 decrease after the first week after intubation, but individual SARS-CoV-2 RNA levels can show a relapsing pattern. Larger studies are needed to address the association of clearance of SARS-CoV-2 RNA from respiratory samples with survival, because we observed a trend towards better survival in patients with early clearance from sputum.
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Journal of critical care · Aug 2021
Quality of life after sepsis and its association with mortality among sepsis survivors in South Korea: A population level cohort study.
This study aimed to investigate the incidence and effect of quality of life (QOL) change in Korean sepsis survivors. ⋯ We found that most sepsis survivors experienced a worsening in their QOL, which was associated with a higher risk of long-term mortality.
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Journal of critical care · Aug 2021
Impact of sterile leukocyturia on outcome of critically ill patients with severe acute kidney injury.
The role of immunological mechanisms on renal regeneration and functional recovery after an episode of Acute Kidney Injury (AKI) is still understudied. We aim to evaluate the impact of sterile leukocyturia on outcomes of critically-ill AKI patients. ⋯ Sterile leukocyturia was associated with different patient baseline and AKI characteristics and more persistent AKI by both KDIGO criteria. Sterile leukocyturia may represent a surrogate marker of renal inflammation during AKI.