Journal of critical care
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Journal of critical care · Oct 2022
Small, short-term, point-of-care creatinine changes as predictors of acute kidney injury in critically ill patients.
To assess short-term creatinine changes as predictors of acute kidney injury (AKI) when used alone and in combination with AKI risk factors. ⋯ In combination with key risk factors, frequent point-of-care creatinine assessment on arterial blood gases to detect small, short-term creatinine changes provides a robust, novel, low-cost, and rapid method for predicting AKI in critically ill patients.
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Journal of critical care · Oct 2022
Development of a machine learning model for the prediction of the short-term mortality in patients in the intensive care unit.
The aim of this study was to develop and evaluate a machine learning model that predicts short-term mortality in the intensive care unit using the trends of four easy-to-collect vital signs. ⋯ This simple yet powerful new mortality prediction model could be useful for early detection of probable mortality and appropriate medical intervention, especially in rapidly deteriorating patients.
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Journal of critical care · Oct 2022
Observational StudySerum linezolid concentrations are reduced in critically ill patients with pulmonary infections: A prospective observational study.
The concentration-time profile of linezolid varies considerably in critically ill patients. Question of interest is, if the site of infection influences linezolid serum concentrations. ⋯ Linezolid serum concentrations are reduced in patients with pulmonary infections. Future studies should investigate if other linezolid thresholds are needed in those patients due to linezolid pooling in patients´ lung.
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Journal of critical care · Oct 2022
Monitoring and auditing protocol adherence, data integrity and ethical conduct of a randomized clinical trial: A case study.
To categorize, quantify and interpret findings documented in feedback letters of monitoring or auditing visits for an investigator-initiated, peer-review funded multicenter randomized trial testing probiotics for critically ill patients. ⋯ Monitoring and auditing findings predominantly concerned missing documentation with minimal threats to data integrity, patient privacy or safety.
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Journal of critical care · Oct 2022
Impact of colonization with multidrug-resistant bacteria on the risk of ventilator-associated pneumonia in septic shock.
The objective is to identify the risk markers of multi-drug resistant bacteria (MDRB) related ventilator-associated pneumonia (VAP) in septic shock patients with previous MDRB carriage. ⋯ Imported and acquired MDRB carriage harbor different risks of subsequent MDRB-related VAP in patients with septic shock.