Journal of critical care
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Journal of critical care · Oct 2024
EditorialWhat every intensivist should know about: The value of limitations in clinical research.
Not applicable.
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Journal of critical care · Oct 2024
Association between comorbidities at ICU admission and post-Sepsis physical impairment: A retrospective cohort study.
Few studies have measured the association between pre-existing comorbidities and post-sepsis physical impairment. The study aimed to estimate the risk of physical impairment at hospital discharge among sepsis patients, adjusting for pre-existing physical impairment prior to ICU admission and in-hospital mortality. ⋯ Pre-existing comorbidities prior to ICU admission were not associated with an increased risk of physical impairment at hospital discharge among sepsis patients after adjusting for baseline covariates and in-hospital mortality.
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Journal of critical care · Oct 2024
Observational StudyHigh PEEP/low FiO2 ventilation is associated with lower mortality in COVID-19.
The positive end-expiratory pressure (PEEP) strategy in patients with coronavirus 2019 (COVID-19) acute respiratory distress syndrome (ARDS) remains debated. Most studies originate from the initial waves of the pandemic. Here we aimed to assess the impact of high PEEP/low FiO2 ventilation on outcomes during the second wave in the Netherlands. ⋯ High PEEP ventilation was associated with improved ICU survival in patients with COVID-ARDS.
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Journal of critical care · Oct 2024
Impact of AKI on metabolic compensation for respiratory acidosis in ICU patients with AECOPD.
Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) can result in severe respiratory acidosis. Metabolic compensation is primarily achieved by renal retention of bicarbonate. The extent to which acute kidney injury (AKI) impairs the kidney's capacity to compensate for respiratory acidosis remains unclear. ⋯ AKI leads to poor outcomes and compromises metabolic compensation of respiratory acidosis in ICU patients with AECOPD. While buffering agents may aid compensation for severe AKI, their use should be approached with caution.