Journal of critical care
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Journal of critical care · Jun 2024
Malglycemia in the critical care setting. Part III: Temporal patterns, relative potencies, and hospital mortality.
The relationship between critical care mortality and combined impact of malglycemia remains undefined. ⋯ Absolute and relative hypoglycemia occurred largely in the first 24 h. Relative to all hypoglycemia, the associated mortality from the seemingly less potent but consistently more prevalent hyperglycemia steadily accumulated with increasing length-of-stay. This has important implications for interpretation of study results.
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Journal of critical care · Jun 2024
Practices surrounding antimicrobial use in patients managed with extracorporeal membrane oxygenation: An international survey.
This study aimed to survey critical care clinicians and characterize their perception of antimicrobial dosing strategies in patients receiving extracorporeal membrane oxygenation (ECMO). ⋯ Approaches to antimicrobial dosing strategies do not significantly differ among respondents between critically ill patients on ECMO support, compared to patients with equal severity of illness not receiving ECMO support. These findings were unexpected considering the added physiologic complexity of the ECMO circuit to critically ill adult patients and the need for well designed and adequately powered studies to inform empiric dosing guidance for ECMO-supported patients.
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Journal of critical care · Jun 2024
Observational StudyAcute kidney injury in patients before and after extracorporeal membrane oxygenation (ECMO) - Retrospective longitudinal analysis of the hospital outcomes.
Acute Kidney Injury (AKI) occurs in up to 85% of patients managed by ECMO support. Limited data are available comparing the outcomes among patients who develop AKI before and after ECMO initiation. ⋯ AKI before ECMO initiation and the need for RRT post-ECMO are independently associated with poor patient survival.