Journal of critical care
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Journal of critical care · Aug 2021
Acidemia subtypes in critically ill patients: An international cohort study.
To study the prevalence, characteristic, outcome, and acid-base biomarker predictors of outcome for different acidemia subtypes. ⋯ In ICU patients with acidemia, mortality differs according to subtype and is highest in the combined subtype. Best acid-base predictors of mortality also differ according to subtype with best performance for pH in combined, SBE in metabolic, and PaCO2 in respiratory acidemia.
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Journal of critical care · Aug 2021
Timing of continuous renal replacement therapy in severe acute kidney injury patients with fluid overload: A retrospective cohort study.
We aimed to evaluate the association of early versus late initiation of Continuous renal replacement therapy (CRRT) with mortality in patients with fluid overload. ⋯ Early initiation of CRRT was independently associated with survival benefits in severe AKI patients with fluid overload.
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Journal of critical care · Aug 2021
Hyperactive delirium in patients after non-traumatic subarachnoid hemorrhage.
Hyperactive delirium is common after subarachnoid hemorrhage (SAH). We aimed to identify risk factors for delirium and to evaluate its impact on outcome. ⋯ Our data indicate that hyperactive delirium is common after SAH patients and requires a certain degree of brain connectivity based ono the highest prevalence found in SAH patients with intermediate outcomes.
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Journal of critical care · Aug 2021
Viral load dynamics in intubated patients with COVID-19 admitted to the intensive care unit.
Prolonged viral RNA detection in respiratory samples from patients with COVID-19 has been described, but the clinical relevance remains unclear. We studied the dynamics of SARS-CoV-2 on a group and individual level in intubated ICU patients. ⋯ In general SARS-CoV-2 RNA levels in respiratory samples in patients with severe COVID-19 decrease after the first week after intubation, but individual SARS-CoV-2 RNA levels can show a relapsing pattern. Larger studies are needed to address the association of clearance of SARS-CoV-2 RNA from respiratory samples with survival, because we observed a trend towards better survival in patients with early clearance from sputum.