Journal of critical care
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Journal of critical care · Aug 2021
Multicenter StudyBacteremia in critically ill immunocompromised patients with acute hypoxic respiratory failure: A post-hoc analysis of a prospective multicenter multinational cohort.
The characteristics and impact of bacteremia have not been widely investigated in immunocompromised patients with acute respiratory failure (ARF). ⋯ We analyzed a large population of immunocompromised patients with ARF and an incidence of bacteremia of 17%. We could not demonstrate an impact of bacteremia on mortality after adjusting for baseline characteristics.
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Journal of critical care · Aug 2021
Urinary and renal oxygenation during dexmedetomidine infusion in critically ill adults with mechanistic insights from an ovine model.
Examine effects of dexmedetomidine on bladder urinary oxygen tension (PuO2) in critically ill patients and delineate mechanisms in an ovine model. ⋯ Dexmedetomidine decreases PuO2in critically ill patients and in sheep. In sheep this reflects a decrease in renal medullary oxygenation, associated with reductions in cardiac output, blood pressure and renal blood flow.
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Journal of critical care · Aug 2021
Recall of clinical trial participation and attrition rates in survivors of acute respiratory distress syndrome.
To measure the rate of recall of study participation and study attrition in survivors of acute respiratory distress syndrome(ARDS). ⋯ One in 4 ARDS survivors do not recall their participation in a clinical trial during hospitalization 3 months following hospital discharge, which did not influence 6-month attrition. However, more patients recall study participation if reconsent is obtained.
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Journal of critical care · Aug 2021
Common biomarkers of physiologic stress and associations with delirium in patients with intracerebral hemorrhage.
To examine associations between physiologic stress and delirium in the setting of a direct neurologic injury. ⋯ Stress-related biomarkers corresponding to multiple organ systems are associated with ICH-related delirium. Early NLR elevation may also predict delayed-onset delirium, potentially implicating systemic inflammation as a contributory delirium mechanism.