Journal of critical care
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Journal of critical care · Feb 2021
Association of gender, age, and race on renal outcomes and mortality in patients with severe sepsis and septic shock.
The association of age, gender and race with renal outcomes in patients with severe sepsis and septic shock (SEP) is not completely elucidated. We aimed to shed light on these relationships. ⋯ Female gender is associated with a lower risk of poor renal outcomes and death among patients with SEP, while AA race places patients at higher risk of poor outcomes in that setting. Increasing age is generally associated with adverse outcomes.
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Journal of critical care · Feb 2021
Levetiracetam pharmacokinetics in critically ill patients undergoing renal replacement therapy.
To determine clearance of levetiracetam in patients requiring continuous renal replacement therapy (CRRT) or sustained low efficiency dialysis (SLED). ⋯ Levetiracetam clearance was substantial with both modalities under the operating conditions reported. There is the potential for subtherapeutic concentrations with current recommended dosing strategies that account only for kidney function and not these extracorporeal routes of elimination.
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Journal of critical care · Feb 2021
Tuberculous ARDS is associated with worse outcome when compared with non-tuberculous infectious ARDS.
Patients with tuberculosis (TB) developing acute respiratory distress syndrome (ARDS) may have a higher mortality when compared with ARDS of other infectious etiology. ⋯ Patients with TB-ARDS presented sicker and had higher mortality when compared with ARDS due to non-TB infectious etiology.
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Journal of critical care · Feb 2021
Observational StudyDischarge from hospital with newly administered antipsychotics after intensive care unit delirium - Incidence and contributing factors.
Delirium in the intensive care unit (ICU) is often treated with haloperidol or atypical antipsychotics. Antipsychotic treatment can lead to severe adverse effects and excess mortality. After initiation in the ICU, patients are at risk of having their antipsychotics continued unnecessarily at ICU and hospital discharge. This study aims to determine the incidence of, and risk factors for antipsychotic continuation at hospital discharge after ICU delirium. ⋯ Approximately one in five patients were discharged from the hospital with continued antipsychotics. Hospital policies should implement strategies for systematic antipsychotic tapering and better follow-up of antipsychotics at transitions of care.
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Journal of critical care · Feb 2021
Mental health status of Chinese physicians working in intensive care unit.
Physicians working in intensive care unit (ICU) are prone to suffer from mental health problems, but there are still very limited data of mental health status of ICU physicians in China. Therefore, this study was to investigate their psychological status. ⋯ The situation of psychological health of ICU physicians in China is worrying, and it is urgent to take some effective measures to improve their mental health.