Journal of critical care
-
Journal of critical care · Dec 2020
Meropenem dosing recommendations for critically ill patients receiving continuous renal replacement therapy.
To gather available meropenem pharmacokinetics and define drug dosing regimens for Asian critically ill patients receiving CRRT. ⋯ A meropenem regimen of 750 mg q 8 h was recommended for Asian critically ill patients receiving 2 different CRRT modalities with standard and high effluent rates. Clinical validation of these results is needed.
-
Journal of critical care · Dec 2020
Observational StudyElevated blood pressure after craniotomy: A prospective observational study.
Close hemodynamic monitoring after craniotomy is routine given risk for post-operative hypertension, systemic and neurological complications. Patient and peri-operative variables associated with increased risk of post-craniotomy hypertension and complications are not well understood. Our analysis aims to estimate the incidence and prevalence of post-craniotomy hypertension, its time course, contributing factors, and post-craniotomy complications. ⋯ Development of hypertension after craniotomy is multi-factorial. In this prospective study, a prior history of hypertension was the only associated independent risk factor.
-
Journal of critical care · Dec 2020
Observational StudyEarly mortality in critical illness - A descriptive analysis of patients who died within 24 hours of ICU admission.
To describe patients who die within 24 h of ICU admission in order to better optimize care delivery. ⋯ Patients who die within 24 h constitute one third of ICU deaths. Age, acuity, admission from the ED and surgical, neurologic or trauma-related admission diagnosis correlate with early death.
-
Journal of critical care · Dec 2020
The ONTAI study - a survey on antimicrobial dosing and the practice of therapeutic drug monitoring in German intensive care units.
Optimization of antibiotic therapy is still urgently needed in critically ill patients. The aim of the ONTAI survey (online survey on the use of Therapeutic Drug Monitoring of antibiotics in intensive care units) was to evaluate which strategies intensive care physicians in Germany use to improve the quality of antibiotic therapy and what role a Therapeutic Drug Monitoring (TDM) plays. ⋯ German intensive care physicians are convinced of TDM for dose optimization. However, practical implementation, the determination of MICs and defined target values are still lacking.