Journal of critical care
-
Journal of critical care · Aug 2019
Comparative Study Observational StudyEvaluation of MR-proANP and copeptin for sepsis diagnosis after burn injury.
The significance of the validated biomarkers of sepsis Mid-regional pro-atrial natriuretic peptide (MR-proANP) and copeptin have not been tested in a burn injury setting. ⋯ Burn injury itself maybe associated with copeptin and to a lesser degree MR-proANP level increases. Subsequent increases in MR-proANP may be considered diagnostic for sepsis but demonstrated no advantages over PCT. The role of copeptin remains inappropriate for diagnosing sepsis after burn injury (ClinicalTrials.gov number, NCT01055587).
-
Journal of critical care · Aug 2019
Review Meta AnalysisEffects of post-ICU follow-up on subject outcomes: A systematic review and meta-analysis.
The present systematic review and meta-analysis aimed to synthesize data on subject outcomes associated with post-ICU follow-up. ⋯ Post-ICU follow-up may improve depression symptoms and mental health-related quality of life in the short term for models focusing on physical therapy and PTSD symptoms in the medium term for models focusing on psychological or medical management interventions.
-
Journal of critical care · Aug 2019
Review Meta AnalysisConstipation, diarrhea, and prophylactic laxative bowel regimens in the critically ill: A systematic review and meta-analysis.
Prophylactic laxative bowel regimens may prevent constipation in enterally-fed critically ill patients. However, their use may also increase diarrhea. We performed a systematic review to: 1. Explore the epidemiology of constipation and/or diarrhea in critically ill patients; and 2. Appraise trials evaluating prophylactic laxative bowel regimens. ⋯ Constipation and diarrhea occur frequently in the critically ill but data evaluating prophylactic laxative bowel regimens in such patients are sparse and do not support their use.
-
Journal of critical care · Aug 2019
Randomized Controlled Trial Multicenter Study Comparative StudyHigh versus low mean arterial pressures in hepatorenal syndrome: A randomized controlled pilot trial.
There is controversy regarding the mean arterial pressure (MAP) goals that should be targeted in the treatment of hepatorenal syndrome (HRS.) We conducted a study to assess different MAP targets in HRS in the intensive care unit (ICU).
-
Journal of critical care · Aug 2019
ReviewMajor publications in critical care pharmacotherapy literature in 2018.
To summarize selected original critical care pharmacotherapy research published in 2018. ⋯ This clinical review and expert commentary of impactful critical care pharmacotherapy publications in 2018 provides perspectives and insights for the critical care practitioner.