Journal of critical care
-
Journal of critical care · Aug 2019
Observational StudyChanges of plasma acetylcholine and inflammatory markers in critically ill patients during early enteral nutrition: A prospective observational study.
Acetylcholine (Ach) is the key anti-inflammatory transmitter in the cholinergic anti-inflammatory pathway. In this study, critically ill patients treated with early enteral nutrition (EEN) were observed to explore whether EEN affected Ach levels and inflammation. ⋯ The administration of EEN to critically ill patients contributed to the increased plasma Ach levels and decreased inflammatory markers. The effect of EEN on Ach levels is partially attributed to the increase in CCK levels. Elevated plasma Ach levels indicate a better prognosis. Clinical trials identifier: NCT03612206.
-
Journal of critical care · Aug 2019
Observational StudyOpportunities for achieving resuscitation goals during the inter-emergency department transfer of severe sepsis patients by emergency medical services: A case series.
This study aimed to describe the care provide by Emergency Medical Services (EMS) to severe sepsis patients being transferred between acute care hospitals and identify how that care contributes to sepsis care goals. ⋯ EMS sepsis care during transfer was limited. EMS crews primarily continued treatments previously initiated and did not take additional steps toward resuscitation targets. Data suggests the inter-emergency department transfer period may provide an opportunity to continue working toward treatment targets, though the time is currently underutilized.
-
Journal of critical care · Aug 2019
Contributors to frailty in critical illness: Multi-dimensional analysis of the Clinical Frailty Scale.
Frailty in critical illness is common and associated with poor outcomes, however little is known about contributing factors. We compared the Clinical Frailty Scale (CFS) with a multi-dimensional validated tool, the Edmonton Frail Scale (EFS), and investigated which health domains are affected by frailty in ICU. ⋯ Frailty in the critically ill affects a range of health deficits, adequately measured via the CFS.
-
Journal of critical care · Aug 2019
Comparative Study Observational StudyCreatinine versus cystatin C based glomerular filtration rate in critically ill patients.