Journal of critical care
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Journal of critical care · Dec 2018
Multicenter Study Comparative StudyComparison of acute kidney injury risk associated with vancomycin and concomitant piperacillin/tazobactam or cefepime in the intensive care unit.
The objective of this study was to evaluate AKI incidence with concomitant vancomycin and piperacillin/tazobactam (PTZ) compared to vancomycin and cefepime (FEP) in critically ill patients. ⋯ Concomitant PTZ and vancomycin in ICU patients was not associated with an increased risk of developing AKI compared to FEP and vancomycin combinations. More patients administered vancomycin/PTZ received RRT.
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Journal of critical care · Dec 2018
Randomized Controlled TrialEffects of designated leadership and team-size on cardiopulmonary resuscitation: The Basel-Washington SIMulation (BaWaSim) trial.
During cardiopulmonary resuscitation (CPR), it remains unclear whether designating an individual person as team leader compared with emergent leadership results in better team performance. Also, the effect of CPR team size on team performance remains understudied. ⋯ Within this international US/Swiss trial, leadership designation and larger team size did not improve hands-on time, but emergent leadership teams initiated defibrillation earlier. Improvements in performance may be more likely to be achieved by optimization of emergent leadership than increasing the size of cardiac arrest teams.
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Journal of critical care · Dec 2018
Randomized Controlled TrialFurosemide and Albumin for Diuresis of Edema (FADE): A parallel-group, blinded, pilot randomized controlled trial.
To assess the feasibility of a trial evaluating whether hyperoncotic albumin, in addition to diuretics, improves diuresis and facilitates liberation from mechanical ventilation in critically ill adults. ⋯ The current study design did not demonstrate feasibility, but can inform the design of a definitive trial.
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Journal of critical care · Dec 2018
One-year mortality of patients admitted to the intensive care unit after in-hospital cardiac arrest: a retrospective study.
Little is known about long-term survival after In-Hospital Cardiac Arrest (IHCA). The purpose of this study is to report the one-year survival of patients after IHCA and to identify predicting factors. ⋯ One-year survival of patients admitted to the ICU after IHCA was 26%. Severity of disease pre-arrest and at ICU-admission could prove useful in prognostication. No multivariate model could be constructed and large prospective studies are needed to elicit the role of pre-arrest factors on survival.
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Journal of critical care · Dec 2018
Risk of de novo infection following acute kidney injury: A retrospective cohort study.
Recent studies suggest that acute kidney injury (AKI) can affect distant organ function and increase non-renal complications. We determined whether AKI is associated with an increased risk of incident infections. ⋯ AKI was associated with incident in-hospital infections. However, newly occurring infections were not associated with an increased risk of mortality. Further studies are needed to understand how AKI affects distant organ function and associated clinical outcomes.