Journal of critical care
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Journal of critical care · Oct 2018
Observational StudyToll-like receptor 2, 4 and 9 polymorphisms and their association with ICU-acquired infections in Central Greece.
To test the potential of four common Toll-like receptor (TLR) polymorphisms to predispose to specific intensive care unit (ICU)-acquired infections and affect outcomes in a Greek ICU. ⋯ Common TLR-signaling polymorphisms might be implicated in the clinical phenotype of ICU-acquired infections in Central Greece. The possible impact of TLR4 polymorphisms on enhanced susceptibility towards Gram-negative MDR-infections in defined critical-disease states warrants further investigation. Trial Registration Clinical Trials.gov identifier: NCT00932243.
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Journal of critical care · Oct 2018
Non-invasive positive pressure ventilation in lung transplant recipients with acute respiratory failure: Beyond the perioperative period.
The purpose of this study is to evaluate outcomes in MICU lung transplant recipients with acute respiratory failure treated with non-invasive positive pressure ventilation (NPPV) and identify factors associated with NPPV failure (need for intubation). ⋯ NPPV is a viable option for lung transplant recipients with acute respiratory failure. Extreme caution should be exercised when used in patients with high severity of illness (APACHE III >78) and/or severe hypoxemia (PaO2/FiO2 ≤ 151).
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Journal of critical care · Oct 2018
Evaluating the risk profile of quetiapine in treating delirium in the intensive care adult population: A retrospective review.
Dosing regimens of quetiapine to treat delirium in critically ill patients are titrated to effect, and may utilize doses higher than previously reported. This study aimed to assess the safety of quetiapine for this indication. ⋯ The dose of quetiapine has very little correlation with QTc and change from baseline. A small number of side effects were observed. Overall, titrating quickly to large doses of quetiapine is safe for treating delirium.
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Journal of critical care · Oct 2018
Observational StudyImpact of acute kidney injury on neurological outcome and long-term survival after cardiac arrest - A 10 year observational follow up.
Acute kidney injury (AKI) may be associated with short- and long-term patient morbidity and mortality. Therefore, the impact of AKI after cardiac arrest on survival and neurological outcome was evaluated. ⋯ Our data suggest that AKI is a major risk factor for a poor neurological outcome and a higher mortality after cardiac arrest. Further important risk factors were age, time to ROSC and high NSE.