Journal of critical care
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Journal of critical care · Jun 2018
Physical function impairment in survivors of critical illness in an ICU Recovery Clinic.
The aims were to 1) determine feasibility of measuring physical function in our ICU Recovery Clinic (RC), 2) determine if physical function was associated with 6-month re-hospitalization and 1-year mortality and 3) compare ICU survivors' physical function to other comorbid populations. ⋯ Physical function measurement in a recovery clinic is feasible and may inform subsequent morbidity and mortality.
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Journal of critical care · Jun 2018
Observational StudyHealthcare-associated ventriculitis and meningitis in a neuro-ICU: Incidence and risk factors selected by machine learning approach.
To define the incidence of healthcare-associated ventriculitis and meningitis (HAVM) in the neuro-ICU and to identify HAVM risk factors using tree-based machine learning (ML) algorithms. ⋯ We first reported HAVM incidence in a neuro-ICU in Russia. We showed that tree-based ML is an effective approach to study risk factors because it enables the identification of nonlinear interaction across factors. We suggest that the number of found risk factors and the duration of their presence in patients should be reduced to prevent HAVM.
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Journal of critical care · Jun 2018
Observational StudyEffect of hypercapnia on respiratory and peripheral skeletal muscle loss during critical illness - A pilot study.
Critical illness has profound effects on muscle strength and long-term physical morbidity. However, there remains a paucity of evidence for the aetiology of critical illness related weakness. Recent animal model research identified that hypercapnia may reduce the rate of muscle loss. The aim of this study was to determine the effect of hypercapnia on respiratory and peripheral skeletal muscle in patients with critical illness. ⋯ In this pilot study, peripheral skeletal muscle weakness occurred early and rapidly within the critical care population, irrespective of carbon dioxide levels.
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Journal of critical care · Jun 2018
Isoflurane or propofol sedation in patients with targeted temperature management after cardiopulmonary resuscitation: A single center study.
Targeted temperature management improves outcomes in comatose patients after cardiac arrest. Short lasting sedatives might enable rapid awakening after targeted temperature management and therefore early prognostication and extubation. Aim of the present study was to compare sedation with volatile isoflurane to intravenous propofol. ⋯ Isoflurane sedation is feasible on during targeted temperature management. Time to spontaneous breathing, mechanical ventilation duration or ICU stay was not reduced by isoflurane.
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Journal of critical care · Jun 2018
Role of Ulinastatin, a trypsin inhibitor, in severe acute pancreatitis in critical care setting: A retrospective analysis.
To evaluate the clinical utility of Ulinastatin, a multifunctional serine protease inhibitor, in the management of severe acute pancreatitis. ⋯ Ulinastatin treatment was associated with improved outcomes in patients with severe acute pancreatitis.