Journal of critical care
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Journal of critical care · Dec 2023
The association between increasing fluid balance, acute kidney injury and mortality in patients with sepsis and septic shock: A retrospective single center audit.
To determine whether a positive fluid balance is associated with AKI and mortality in sepsis and septic shock patients. ⋯ In patients with sepsis and septic shock, a more positive fluid balance is associated with an increased incidence of acute kidney injury and death after correction for possible confounders.
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Journal of critical care · Dec 2023
Early renal recovery after acute kidney injury in patients on venoarterial extracorporeal membrane oxygenation: A retrospective study.
The impact of VA-ECMO on early renal recovery (within 7 days after ECMO onset) in patients with pre-ECMO acute kidney injury and cardiogenic shock is unknown. ⋯ Only 43% of patients with severe pre-ECMO AKI had early renal recovery after VA-ECMO initiation.
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Journal of critical care · Dec 2023
Prognosis of critically ill patients with extreme acidosis: A retrospective study.
This study aims to assess the impact of different subtypes of extreme acidosis on the mortality of critically ill patients. ⋯ Among critically ill patients with extreme acidosis, the primary disorder is not associated with mortality, but it is associated with the use of vasopressors and MV, the duration of MV, and the length of ICU and hospital stay. Additionally, hyperlactatemia is a predictor of poor prognosis in patients with extreme acidosis.
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Journal of critical care · Dec 2023
Critically ill patients: Histopathological evidence of thyroid dysfunction.
Critical illness is characterized by severe biphasic physical and metabolic stress as result of systemic inflammatory response syndrome and/or multiple organ dysfunction syndrome, and is frequently associated with non-thyroidal illness. Purpose of this study is to better understand the cytomorphological basis of NTI by performing histopathological examinations of thyroid gland on autopsies of patients who died from critical illness. ⋯ Critical illness produces metabolically damaging effects on thyroid gland, which functionally corresponds to a state of low T3 syndrome. These changes are more pronounced in BI and cerebral stroke than in TBI.
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Journal of critical care · Dec 2023
Population pharmacokinetics and model-based dosing optimization of teicoplanin in elderly critically ill patients with pneumonia.
To evaluate the population pharmacokinetics and pharmacodynamics of teicoplanin in elderly critically ill patients with pneumonia for optimal dosages. ⋯ Standard teicoplanin dosages for pneumonia may provide inadequate systemic exposures in elderly critically ill patients. High-dose regimens should be considered as empiric therapy or for less susceptible pathogens.