Journal of critical care
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Journal of critical care · Oct 2015
Multicenter Study Observational StudyDecrease of oxidative phosphorylation system function in severe septic patients.
The comparison of oxidative phosphorylation system capacities between septic patients and control subjects has been scarcely analyzed and only in studies with small sample size (fewer than 40 septic patients and 40 controls). Thus, the objective of this study was to compare platelet respiratory complex IV (CIV) activity between severe septic patients and healthy individuals in a larger series (including 198 severe septic patients and 96 healthy controls). ⋯ The major finding of our work, involving the largest series to date of severe septic patients with data on oxidative phosphorylation system capacity, was that surviving and nonsurviving septic patients showed lower platelet CIV-specific activity during the first week of sepsis than healthy controls.
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Journal of critical care · Oct 2015
Multicenter StudySharing intimacy in "open" intensive care units.
Opening intensive care units (ICUs) is particularly relevant because of a new Swiss law granting the relatives of patients without decision-making capability a central role in medical decisions. The main objectives of the study were to assess how the presence of relatives is viewed by patients, health care providers, and relatives themselves and to evaluate the perception of the level of intrusiveness into the personal sphere during admission. ⋯ Relatives in these "open" ICUs share a great deal of intimacy with the patients. Their presence and the deriving benefits were seen as very positive by patients and relatives themselves. Skepticism, instead, prevailed among health care providers.
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Journal of critical care · Oct 2015
Multicenter StudyFamilies' experiences of intensive care unit quality of care: Development and validation of a European questionnaire (euroQ2).
The purpose of the study is to adapt and provide preliminary validation for questionnaires evaluating families' experiences of quality of care for critically ill patients in the intensive care unit (ICU). ⋯ The questions were assessed as relevant and understandable, providing high face and content validity. Ceiling effects were comparable to similar instruments; missing data, low; and test-retest reliability, acceptable. These measures are promising for use in research, but further validation is needed before they can be recommended for routine clinical use.
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Journal of critical care · Oct 2015
Multicenter StudyPostintubation hypotension in intensive care unit patients: A multicenter cohort study.
To determine the incidence of postintubation hypotension (PIH) and associated outcomes in critically ill patients requiring endotracheal intubation. ⋯ The development of PIH is common in ICU patients requiring emergency airway control and is associated with poor patient outcomes.
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Journal of critical care · Oct 2015
Multicenter Study Observational StudySepsis may not be a risk factor for mortality in patients with acute kidney injury treated with continuous renal replacement therapy.
We aimed to study the clinical characteristics, courses, and outcomes of critically ill patients with septic acute kidney injury (AKI) treated with continuous renal replacement therapy (CRRT) in comparison with nonseptic AKI treated with CRRT. ⋯ Sepsis may not be a risk factor for mortality in patients with AKI whose condition has become severe enough to require CRRT.