Journal of critical care
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Journal of critical care · Aug 2011
Quality of life 9 years after an intensive care unit stay: a long-term outcome study.
The purpose of the study was to assess long-term mortality after an intensive care unit (ICU) stay and to test the hypotheses that (1) quality of life improves over time and (2) predictions of outcome made by caregivers during an ICU stay are reliable. ⋯ Mortality is high 9 years after ICU stay. Quality of life may deteriorate for some individuals; however, overall quality of life for most survivors remains acceptable and may even improve. Long-term outcome predictions made by caregivers during the ICU stay seem accurate.
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Journal of critical care · Aug 2011
Correlation between coagulopathy and outcome in severe head trauma in neurointensive care and trauma units.
Abnormal blood coagulation after traumatic brain injury is a common finding. Some studies have proposed these changes as useful predictors of outcome in patients with head trauma. This study aimed at evaluating the association of the routine tests of blood coagulation within the first hours after severe head trauma with prognosis of patients with severe head trauma. ⋯ On-admission PT, PTT, INR and platelet count may be used as predictors of outcome and prognosis of patients with severe head trauma.
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Journal of critical care · Aug 2011
Increased myeloperoxidase enzyme activity in plasma is an indicator of inflammation and onset of sepsis.
Circulating lipopolysaccharides released from bacteria may activate both neutrophils and monocytes. The activated neutrophils release myeloperoxidase (MPO), a specific enzyme with strong oxidative activity. The aim of this study was to evaluate MPO enzyme activity in plasma of critically ill patients and to check the hypothesis that these concentrations in plasma would be higher in sepsis and systemic inflammatory conditions, as neutrophils release their contents before proliferating in response to stress. ⋯ The plasma MPO concentrations may be a marker of the neutrophil proliferation and severity of inflammation.
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Journal of critical care · Aug 2011
Comparative StudyComparison of 3 different multianalyte point-of-care devices during clinical routine on a medical intensive care unit.
Multianalyte point-of-care (POC) devices are important to guide clinical decisions in critical care. However, the use of different devices in one hospital might cause problems. Therefore, we evaluated 3 commonly used POC devices and analyzed accuracy, reliability, and bias. ⋯ Although POC devices are of high standard and overall comparability between devices is high, there might be a clinically relevant bias between devices, as found in our study for pO2, BE(B), hemoglobin, and hematocrit. This can be of importance when interpreting results of the same patient obtained from different POC devices, as it could happen when a patient is transferred within a hospital where different devices are used.
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Journal of critical care · Aug 2011
Factors influencing enoxaparin anti-Xa activity in surgical critically ill patients.
The objectives of the present study were to describe the incidence of low anti-Xa levels defined as below 0.1 IU/mL in a general surgical intensive care unit population and to evaluate factors independently influencing anti-Xa activity. ⋯ In the study, prophylactic SC enoxaparin in critically ill patients at the current 30 mg SC twice daily dosage attained an anti-Xa level more than 0.1 U/mL in nearly all patients. In addition, low creatinine clearances and female sex are associated with higher anti-Xa activity AUC(0-12h).