Journal of critical care
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Journal of critical care · Mar 2003
ReviewProcalcitonin as a diagnostic test for sepsis: health technology assessment in the ICU.
Elevation in the serum concentration of procalcitonin (PCT) is associated with systemic infection. This association has led to the proposed use of PCT as a novel biomarker of bacterial sepsis. The advantages and limitations of the American College of Chest Physicians/Society of Critical Care Medicine (ACCP/SCCM) definitions of sepsis are an important consideration that affects the impact of any diagnostic test for sepsis and these issues are discussed. ⋯ The published evidence does not support a general claim that PCT is a useful decision support tool for diagnosing sepsis in patients who have SIRS. Procalcitonin has a slightly better ability to exclude the diagnosis of sepsis. The role for using PCT testing in the ICU will continue to evolve along with our understanding and definition of sepsis.
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Journal of critical care · Mar 2003
ReviewMedical informatics in the intensive care unit: overview of technology assessment.
Effective patient care in the intensive care unit (ICU) depends on the ability of clinicians to process large amounts of clinical and laboratory data. Recently, medical informatics applications have been developed to store and display patient information and assist clinical decision making. Despite the proliferation of these systems and their potential to improve patient care, there are no comprehensive health technology assessments incorporating considerations of safety, functionality, technical performance, clinical effectiveness, economics, and organizational implications. ⋯ Qualitative and quantitative nonrandomized evaluations of comprehensive information management systems like electronic medical records and picture archiving and communications systems should concentrate on technical and functional issues. Specific applications like clinical decision support systems and computerized patient care systems are designed to improve patient outcomes and clinical performance; randomized controlled trials (RCTs) to assess clinical effectiveness are important in their assessment. Although studies of these applications in the ICU setting are increasing, there are currently very few published randomized trials.
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Journal of critical care · Mar 2003
Review Comparative StudyAcute renal failure in the ICU: assessing the utility of continuous renal replacement.
Acute renal failure (ARF) in the ICU patient still remains a common problem and is associated with increased morbidity, mortality, and cost. Potential advantages of continuous renal replacement (CRRT), compared with intermittent hemodialysis (IHD) include enhanced hemodynamic stability, increased solute removal, and greater ultrafiltration. ⋯ The difficulties associated with designing such prospective studies are the complex status of the medical patients and the ethical dilemma of randomizing patients to a certain dialysis modality. At this time, there is no evidence to support the assertion that CRRT improves clinical outcomes compared with IHD.
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Journal of critical care · Mar 2003
End-of-life intensive care unit decisions, communication, and documentation: an evaluation of physician training.
The majority of patients dying in intensive care units (ICUs) do so after the forgoing of life-sustaining therapies (FLST). Communication between physicians, patients, and their families regarding the decision to FLST has not been evaluated in Israel. ⋯ FLST is common in an Israeli ICU. Patients are not medically competent to make FLST decisions. American-trained physicians discuss and document FLST more often than Eastern European-trained physicians.