Pediatric hematology and oncology
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A patient suffering from infantile-onset insulin-dependent diabetes mellitus is reported in whom immune pancytopenia (Evans' syndrome) developed at the age of 2 1/2 years. Hepatosplenomegaly, chronic lymphadenopathy, and elevated levels of immunoglobulins G and M were also present. The course of Evans' syndrome was fatal in this patient. The association of Evans' syndrome with other immune disorders is discussed.
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Pediatr Hematol Oncol · Jan 1998
Serum interleukin-2 and interleukin-6 levels in iron deficiency anemia.
The aim of this study was to investigate the serum levels of interleukin-2 (IL-2) and interleukin-6 (IL-6) in children with iron deficiency anemia before and after iron supplementation. Twenty-five children with iron deficiency anemia 6 months to 3 years of age were included in the study. ⋯ In the iron-deficiency group the production of IL-2 was found to be significantly lower than that in controls and became normal after iron supplementation (P < .001). But there was no difference in serum levels of IL-6 in iron deficiency anemia before and after iron supplementation (P > .05).
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The Manchester pediatric oncology unit is the third largest unit in the United Kingdom, with approximately 120 new referred cases per annum (10% of the U. K. total). Research activities include a gene therapy program, peripheral blood stem cell studies, the genetic epidemiology of childhood cancer, late-effects research (growth, body composition, pulmonary, quality of life), psychosocial studies, and clinical trial organization. ⋯ The unit contains the second largest children's hemophilia service in the United Kingdom, serving 200 patients with congenital blood disorders. Twenty-five bone marrow transplants are performed each year (allogeneic, unrelated donor, autologous, and peripheral stem cell) for malignant and nonmalignant disorders. These activities are closely related to local, national, and international research groups.
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Pediatr Hematol Oncol · May 1997
ReviewAcademic pediatrics in the Emma Children's Hospital, Academic Medical Center in Amsterdam (The Netherlands).
In 1988 the Emma Children's Hospital and the department of pediatrics of the Academic Medical Center in Amsterdam (The Netherlands) merged. With the integration of the Emma Children's Hospital and the academic pediatric department, an academic children's hospital (ECH/ AMC) was established with all pediatric subspecialties including oncology, pediatric hematology/ hemostasis, and immunology. The research is organized in special research institutes. ⋯ Considerable effort is given to the care of patients with hemophilia and congenital clotting disorders. One of the special fields in immunology is the care for children infected with human immunodeficiency virus (HIV). The Emma Children's Hospital AMC participates in national and international programs for human immunodeficiency virus and AIDS research and immunological diseases, especially chronic granulomatous disease, in which an internationally appreciated know-how has been built up.
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Pediatr Hematol Oncol · May 1997
Clinical TrialOutpatient antimicrobial protocol for febrile neutropenia: a nonrandomized prospective trial using ceftriaxone, amikacin, and oral adjuvant agents.
Broad-spectrum antimicrobial therapy has revolutionized the management of febrile neutropenia (FN) in cancer patients. In vogue is an effective therapy an an outpatient basis. One thousand three hundred episodes of FN observed in 70 pediatric solid tumors (STs) and 65 cases of hematomalignancy (HM) at a median age of 5.5 years were treated with a protocol using once-a-day injectable ceftriaxone plus amikacin and other oral adjuvant antimicrobial agents. ⋯ The overall recrudescence rate was 6% and the mean duration to recrudescence was 4 +/- 1.5 days (range 3-6 days). The objectives of this protocol were cost reduction and utilization of the available inpatient resources optimally by reducing the pressures of hospitalization for febrile neutropenia. We concluded that a selected group of patients with FN can be effectively managed with this regimen on an outpatient basis.