Canadian journal of anaesthesia = Journal canadien d'anesthésie
-
Randomized Controlled Trial Clinical Trial
Prophylactic oral dolasetron mesylate reduces nausea and vomiting after abdominal hysterectomy. The Canadian Dolasetron Study Group.
The incidence of postoperative nausea and vomiting (PONV) varies from 50% to 75% after gynaecological surgery under general anaesthesia. This study evaluates the dose-response relationships, safety, and efficacy of the new 5-HT3 antagonist, dolasetron mesylate, in the prevention of PONV in women undergoing total abdominal hysterectomy (TAH). ⋯ Prophylactic dolasetron (100 mg and 200 mg) reduces the incidence of PONV in patients having total abdominal hysterectomy.
-
Randomized Controlled Trial Clinical Trial
Prostaglandin E1, lidocaine, and prostaglandin E1-lidocaine combination for attenuating cardiovascular responses to extubation.
Tracheal extubation produces haemodynamic changes that may cause myocardial ischaemia in patients with coronary arterial disease. Intravenous infusion of prostaglandin E1 (PGE1) attenuated the hypertensive response to tracheal extubation but failed to blunt the tachycardia, which was attenuated by intravenous lidocaine. Thus, we investigated whether a combination of PGE1 and lidocaine can overcome the drawbacks of treatment with PGE1 alone. ⋯ The combination of PGE1 infusion and lidocaine is a more effective method of attenuating hypertension and tachycardia associated with tracheal extubation than either drug alone.
-
A first case of massive venous air embolism is reported as a complication of orthotopic liver transplantation in a 17-month-old child during the dissection phase. ⋯ Venous air embolism during the dissection phase of liver transplantation in children is a risk that should be considered
-
Lack of financial information results in planning difficulties and may delay the introduction of simulator based education. We collected data from an existing simulation centre and describe a construction and operating budget to facilitate planning and construction for interested institutions. ⋯ Substantial resources are required for the construction of a simulation centre ($665,000) primarily use of capital equipment purchases. However, there is also a considerable operating cost per year ($167,250) which consists mostly of salary support.
-
Randomized Controlled Trial Clinical Trial
Physostigmine increases the dose of propofol required to induce anaesthesia.
This prospective, randomized, double-blind study was performed to determine the effect of administration of physostigmine on the dose of propofol required to produce loss of consciousness. ⋯ Physostigmine pretreatment increases the dose of propofol required to produce loss of consciousness.