Canadian journal of anaesthesia = Journal canadien d'anesthésie
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Randomized Controlled Trial Comparative Study Clinical Trial
Dose response study of lidocaine 1% for spinal anaesthesia for lower limb and perineal surgery.
To compare the sensory and motor block produced by three different volumes of intrathecal lidocaine 1% and thereby determine the appropriate volume to administer for surgery of the lower limbs and perineum. ⋯ Four millilitres intrathecal lidocaine 1% is adequate for perineal surgery but for lower limb procedures, 6 ml is more appropriate as it consistently provides sensory analgesia above L1 dermatome and complete motor block. Eight ml gives an unnecessarily high block with higher incidence of hypotension.
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Randomized Controlled Trial Comparative Study Clinical Trial
Calcium channel blockers attenuate cardiovascular responses to tracheal extubation in hypertensive patients.
Hypertensive patients exhibit exaggerated cardiovascular responses to tracheal extubation. This study was undertaken to examine the inhibitory effects of calcium channel blockers, nicardipine and diltiazem, on haemodynamic changes after tracheal extubation. ⋯ Compared with nicardipine, administration of diltiazem produced greater attenuating the circulatory responses to tracheal extubation in hypertensive patients.
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Randomized Controlled Trial Clinical Trial
Intrathecal sufentanil as the sole agent in combined spinal-epidural analgesia for the ambulatory parturient.
To compare the effect of a combination of intrathecal (i.t.) sufentanil plus bupivacaine with i.t. sufentanil alone, on the incidence of hypotension and the success of ambulation in parturients. ⋯ The quality of analgesia in all subjects in the study was excellent. Side effects were more common in the i.t. sufentanil-bupivacaine combination group.
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Clinical Trial
Epidural analgesia in early labour blocks the stress response but uterine contractions remain unchanged.
To determine the effect of epidural analgesia on biochemical markers of stress, plasma oxytocin concentrations and frequency of uterine contractions during the first stage of labour. ⋯ The metabolic stress response to the pain of labour was attenuated by epidural analgesia. In contrast, plasma oxytocin concentration and frequency of uterine contractions were unaffected by the attenuation of metabolic stress response.