Canadian journal of anaesthesia = Journal canadien d'anesthésie
-
The aims of this study are to determine if the injection of a single large dose of local anesthetics into the paravertebral space increases the risks of inducing toxicity compared with multiple small injections and to describe ropivacaine plasma concentrations resulting from paravertebral blockade. ⋯ The injection of a single large bolus of local anesthetics into the paravertebral space does not increase its absorption. Maximal ropivacaine plasma concentrations resulting from paravertebral blockade are similar to those reported with equivalent doses of bupivacaine.
-
To describe the modification of the ropivacaine (R) pharmacokinetics produced by the addition of epinephrine (E). ⋯ The addition of E significantly modifies the pharmacokinetics of R injected caudally.