Canadian journal of anaesthesia = Journal canadien d'anesthésie
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Complex regional pain syndrome (CRPS) is a chronic inflammatory pain syndrome that affects one or more extremities of the body. It is characterized by burning pain and abnormalities in the sensory, motor, and autonomic nervous systems. This review illustrates how oxidative stress and nuclear factor erythroid 2-related factor (Nrf2) activation might contribute to understanding the etiopathogenesis of CRPS. ⋯ This review summarises the effect of oxidative stress and mitochondrial dysfunction in the pathogenesis of CRPS. It also addresses the question of whether there is a potential role for Nrf2 (activated by pharmacological or nutritional activators) in alleviating the clinical features of CRPS or preventing its progression.
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Artifacts in anesthesia information management system (AIMS) databases may influence research results. Filtering during data capturing can prevent artifacts from being stored. In this prospective study, we assessed the reliability of AIMS data by determining the incidence of artifactual values stored in the AIMS. ⋯ Storing a median value per minute to filter capturing of vital parameter values in an AIMS database provides reliable data for heart rate and oxygen saturation and acceptable reliability for noninvasive blood pressure data. Knowledge about the method of artifact filtering is essential in studies using AIMS data.