Canadian journal of anaesthesia = Journal canadien d'anesthésie
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Addiction to alcohol and illicit drugs occurs in approximately 10% of the Canadian population and thus likely affects numerous perioperative patients. Provision of perioperative analgesia to these patients is challenging for physiological and behavioural reasons. Seven electronic databases were searched to identify papers addressing the perioperative management of analgesia in addicted patients. ⋯ Perioperative analgesic management of addicted patients remains poorly understood. Most clinical trials specifically exclude addicted patients. Suggestions for management are provided.
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This review article explores the need for specialized pain care for children and adolescents and provides some historical context for our current knowledge base and clinical practice. ⋯ Awareness of children's pain has increased dramatically over the past three decades, and Canadians have performed a leadership role in much of the research. Specific multidisciplinary teams are a more recent phenomenon, but they are shown to be more effective and probably more cost effective than traditional treatment models. Important gaps in availability of resources to manage these patients remain.
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Hypoxic pulmonary vasoconstriction (HPV) is a fundamental physiological process whereby ventilation/perfusion matching is optimized through the constriction of the pulmonary circulation supplying poorly ventilated lung units. In their 1981 paper in the Journal, Noble, Kay, and Fisher used a series of animal experiments to show that alveolar carbon dioxide (CO2) plays a critical role in the regulation of hypoxic pulmonary vasoconstriction. At physiological concentrations, CO2 potentiates the HPV response, and the absence of alveolar CO2 blunts HPV. The enhancement of HPV by CO2 resulted in reduced perfusion of specific hypoxic lung regions, thereby improving systemic oxygenation in lung-ventilated dogs.
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This study was undertaken to determine the contribution of postoperative pain to the known changes that occur to respiratory function in the postoperative period. The authors studied changes in functional residual capacity (FRC) and vital capacity (VC) either in the postanesthesia care unit or on postoperative day one in eight relatively healthy adult patients having upper abdominal surgery. ⋯ Epidural analgesia to a T4 sensory level resulted in a partial and statistically significant restoration of VC (from 37-55% of preoperative values) and a partial but statistically insignificant restoration of FRC (from 78-84% of preoperative values). The authors suggest that postoperative epidural analgesia may be able to decrease respiratory complications.