Canadian journal of anaesthesia = Journal canadien d'anesthésie
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Randomized Controlled Trial
Propofol cardioprotection for on-pump aortocoronary bypass surgery in patients with type 2 diabetes mellitus (PRO-TECT II): a phase 2 randomized-controlled trial.
The efficacy of myocardial conditioning strategies is compromised in patients with advanced age, diabetes, or low ejection fraction. We conducted a single-centre parallel-arm blinded randomized-controlled trial to determine whether propofol provides perioperative myocardial protection. ⋯ Propofol may be a preemptive intraoperative cardioprotectant for patients with DM2 under conditions of normothermic CPB and blood cardioplegic arrest. The study is registered at www.clinicaltrials.gov (NCT00734383) and www.controlled-trials.com (ISRCTN70879185).
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Randomized Controlled Trial Comparative Study
A comparison of motor stimulation threshold in ultrasound-guided interscalene brachial plexus block for arthroscopic shoulder surgery: a randomized trial.
As the use of ultrasound for regional anesthesia has increased, many studies have examined the distribution of local anesthetic and the location of the needle tip. Nevertheless, the relationship between motor stimulation threshold and distribution of local anesthetic is unclear. The aim of this study was to compare block onset time, distribution of local anesthetic, and location of the needle tip at two different motor stimulation thresholds, i.e., 0.2 and 0.5 mA, used in combination with ultrasound guidance. ⋯ The onset time of the block was significantly faster with a motor stimulation threshold of 0.2 mA than with a threshold of 0.5 mA.
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Observational Study
Interleukin-1β gene variants are associated with QTc interval prolongation following cardiac surgery: a prospective observational study.
We characterized cardiac surgery-induced dynamic changes of the corrected QT (QTc) interval and tested the hypothesis that genetic factors are associated with perioperative QTc prolongation independent of clinical and procedural factors. ⋯ The results suggest a contribution of IL1β in modulating susceptibility to postoperative QTc prolongation after cardiac surgery.
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Patients with diabetes mellitus have chronic neuropathic pain. The aim of our study was to 1) evaluate the feasibility of providing analgesia with a long-term sciatic perineural catheter in a medical unit for diabetic patients and 2) evaluate its effectiveness. ⋯ The use of sciatic perineural catheters as an alternative analgesia technique in a non-surgical environment for diabetic patients with chronic pain was possible and effective.