Canadian journal of anaesthesia = Journal canadien d'anesthésie
The most recent articles from:
Can J Anaesth
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Observational Study
The association of thrombin generation with bleeding outcomes in cardiac surgery: a prospective observational study.
Cardiac surgery with cardiopulmonary bypass (CPB) is associated with coagulopathic bleeding. Impaired thrombin generation may be an important cause of coagulopathic bleeding but is poorly measured by existing hemostatic assays. We examined thrombin generation during cardiac surgery, using calibrated automated thrombography, and its association with bleeding outcomes. ⋯ Thrombin generation is significantly impaired by CPB and associated with higher bleeding severity. Clinical studies aimed at the identification and treatment of patients with impaired thrombin generation are warranted.