Canadian journal of anaesthesia = Journal canadien d'anesthésie
The most recent articles from:
Can J Anaesth
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The immune system plays an important role in tumour progression. Systemic opioids are immunosuppressive; thus, theoretically they may promote tumour spread. Our primary aim was to test the hypothesis that general anesthesia (GA) with spinal analgesia (SA) in patients with bladder cancer undergoing radical cystectomy (RC) will both reduce systemic opioid use and improve oncological outcomes. Since blood transfusions also induce immunosuppression, a secondary aim was to evaluate the effect of perioperative transfusions on oncological outcomes. ⋯ In patients undergoing RC, the opioid-sparing effect with SA was not associated with improved oncological outcomes, while blood transfusion was associated with increased mortality.
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Letter Randomized Controlled Trial
Efficacy of a simple scavenging system for long-term critical care sedation using volatile agent-based anesthesia.