The Pediatric infectious disease journal
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Pediatr. Infect. Dis. J. · Aug 1999
Multicenter Study Clinical TrialAmphotericin B lipid complex in pediatric patients with invasive fungal infections.
Lipid formulations of amphotericin B have been recently introduced for treatment of invasive fungal infections. However, little is known about their role in pediatric populations. ⋯ These data support the use of ABLC for treatment of invasive fungal infections in pediatric patients who are intolerant of or refractory to conventional antifungal therapy.
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Pediatr. Infect. Dis. J. · Aug 1999
Comparative StudyComparison of procalcitonin with interleukin 8, C-reactive protein and differential white blood cell count for the early diagnosis of bacterial infections in newborn infants.
To evaluate procalcitonin (PCT) as a test for early diagnosis of bacterial infections (BI) in newborn infants and to compare the results of PCT with those of interleukin 8 (IL-8), C-reactive protein (CRP) and differential white blood cell count. ⋯ The combination of IL-8 and CRP is more reliable than PCT as a test for early diagnosis of BI in newborn infants.
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Pediatr. Infect. Dis. J. · Jul 1999
Increased protections during a measles outbreak of children previously vaccinated with a second dose of measles-mumps-rubella vaccine.
In 1989 a second dose of measles vaccine was recommended for US children to prevent school outbreaks of measles. Coverage of school age children with a second dose remains incomplete, and data on the effectiveness of this recommendation are limited. We investigated a measles outbreak in Mesa County, CO, in December, 1994, and evaluated the efficacy of preoutbreak immunizations at an elementary school (School A) where many students had received two doses. ⋯ The lower attack rate among two dose recipients provides evidence that a two dose strategy can help prevent measles in schools. Administering the second dose at elementary school entry can help prevent the persistence of susceptible cohorts of children and is likely to be important in sustaining elimination of indigenous transmission of measles in the United States.