The Pediatric infectious disease journal
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Pediatr. Infect. Dis. J. · Jun 1999
Epiglottitis in Sweden before and after introduction of vaccination against Haemophilus influenzae type b.
Acute epiglottitis is an important manifestation of invasive Haemophilus influenzae type b (Hib) infection. In 1992 and 1993 Hib vaccination was introduced in the general childhood vaccination program in Sweden. The aim of the present investigation was to study the impact of Hib vaccination on the diagnosis of epiglottitis in Sweden in children as well as adults. ⋯ Introduction of Hib vaccination in a general childhood program was followed not only by a >90% reduction in the incidence in the youngest age group but also by a reduction in the incidence in the older age groups and among adults.
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Pediatr. Infect. Dis. J. · Jan 1999
Randomized Controlled Trial Multicenter Study Comparative Study Clinical TrialReactogenicity and immunogenicity of a new live attenuated combined measles, mumps and rubella vaccine in healthy children.
To compare the reactogenicity and immunogenicity of a novel live attenuated measles-mumps-rubella vaccine, SB MMR (Priorix; SmithKline Beecham Biologicals), with a widely used MMR vaccine, Merck MMR (M-M-R II; Merck & Co. Inc). ⋯ When administered as primary vaccination in children in the second year of life, the new SB MMR vaccine has been shown to be superior to a comparator vaccine in terms of local reactogenicity, with equivalent immunogenicity.