Critical care medicine
-
Critical care medicine · Mar 1991
Comparative StudyAge effects susceptibility to pulmonary barotrauma in rabbits.
We studied the effect of age on the development of pulmonary barotrauma after mechanical ventilation with high peak inspiratory pressures (PIP). ⋯ These data indicate that the lungs of young rabbits had a higher baseline microvascular permeability and were more susceptible to the development of ventilator-induced increased microvascular permeability. More compliant lungs and chest wall and the larger distending volumes attained at each peak airway pressure appear to be the mechanisms.
-
Critical care medicine · Mar 1991
Comparative StudySmall-volume resuscitation from hemorrhagic shock in dogs: effects on systemic hemodynamics and systemic blood flow.
This study compared canine systemic hemodynamics and organ blood flow (radioactive microsphere technique) after resuscitation with 0.8% saline (Na+ 137 mEq/L), 7.2% hypertonic saline (Na+ 1233 mEq/L), 20% hydroxyethyl starch in 0.8% saline, or 20% hydroxyethyl starch in 7.2% saline, each in a volume approximating 15% of shed blood volume. Twenty-four endotracheally intubated mongrel dogs (18 to 24 kg) underwent a 30-min period of hemorrhagic shock, from time 0 to 30 min into the shock period, followed by fluid resuscitation. Data were collected at baseline, 15 min into the shock period, immediately after fluid infusion, 5 min after the beginning of resuscitation, and at 60-min intervals for 2 hr, (65 min after the beginning of resuscitation, and 125 min after the beginning of resuscitation). The animals received one of four randomly assigned iv resuscitation fluids: saline (54 mL/kg), hypertonic saline (6.0 mL/kg), hydroxyethel starch (6.0 mL/kg) or hypertonic saline/hydroxyethyl starch (6.0 mL/kg). ⋯ Small-volume resuscitation with the combination of hypertonic saline/hydroxyethyl starch is comparable with much larger volumes of 0.8% saline, and is equal to hypertonic saline or hydroxyethyl starch in the ability to restore and sustain BP and improve organ blood flow after resuscitation from hemorrhagic shock.
-
Critical care medicine · Mar 1991
Outcome following prolonged intensive care unit stay in multiple trauma patients.
To describe the hospital course and outcomes of trauma patients requiring ICU stays greater than 30 days and the charges they incur. ⋯ Length of ICU stay was most closely associated with the need for mechanical ventilation. The presence of premorbid illness, age greater than 65 yr, and organ dysfunction was associated with increased mortality. Although trauma patients requiring prolonged ICU stays utilize many resources, the ultimate outcome may be fairly good.
-
Critical care medicine · Mar 1991
Comparative StudyAirway pressure release ventilation in a neonatal lamb model of acute lung injury.
To determine if airway pressure release ventilation (APRV) is feasible in a neonatal animal model with acute lung injury. ⋯ In this neonatal laboratory model of acute lung injury, APRV maintained oxygenation and augmented alveolar ventilation compared with CPAP. Compared with PPV, APRV provided similar ventilation and oxygenation, but at lower peak Paw than PPV, without compromising cardiovascular performance.