Critical care medicine
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Critical care medicine · Mar 1993
Use of vitamin B12 in the treatment and prevention of nitroprusside-induced cyanide toxicity.
To review the mechanism of action, safety, and efficacy of hydroxocobalamin in the treatment and prevention of nitroprusside-induced cyanide toxicity. ⋯ Hydroxocobalamin is a safe and effective agent in the prevention and treatment of nitroprusside-induced cyanide toxicity. Prolonged or high-dose infusions of nitroprusside should be minimized in critically ill patients, especially if hepatic and/or renal dysfunction is present.