Critical care medicine
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Critical care medicine · Jul 1994
ReviewBiology of proinflammatory cytokines and their antagonists.
To review the role of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 (IL-1) in the proinflammatory cascade, with particular emphasis on the association between increased concentrations of these cytokines and the sepsis-associated shock syndrome. Data that support the role of these cytokines as proinflammatory mediators provide a rationale for specific anticytokine therapies. ⋯ Induction of inflammation during sepsis is a complex biological cascade that may be effectively attenuated by novel anticytokine biotherapies.
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Critical care medicine · Jul 1994
ReviewDoes the formulation of enteral feeding products influence infectious morbidity and mortality rates in the critically ill patients? A critical review of the evidence.
To examine the relationship between the formulation of enteral nutrition and nosocomial infection in critical illness. ⋯ Insufficient experimental data exist to permit conclusions that enteral nutrition formulations or supplements reduce infectious morbidity and mortality rates, but results are promising enough to warrant further research.
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Critical care medicine · Jul 1994
Comparative StudyThermodilution right ventricular ejection fraction measurements: room temperature versus cold temperature injectate.
To compare thermodilution right ventricular ejection fraction measurements using 10 mL room temperature injectate vs. 10 mL cold temperature injectate. ⋯ The results suggest that room temperature injectate may be used for right ventricular ejection fraction measurements in critically ill adult surgical patients. Utilizing room temperature injectate for right ventricular ejection fraction measurements may save time and costs in the critical care unit.
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a) To examine the clinical utility of transcranial Doppler and continuous-wave Doppler in monitoring nonsurgical patients with severe intracranial disease until intracranial circulatory arrest and brain death; and b) to investigate if hemodynamic phenomena that occur under such conditions are correlated to specific transcranial Doppler and continuous-wave Doppler waveforms. ⋯ Transcranial Doppler offers a noninvasive method to document deterioration of cerebral perfusion pressure and in the future could be included in protocols for brain death diagnosis.
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Critical care medicine · Jul 1994
Comparative Study Retracted PublicationContinuous hemofiltration and platelet function in critically ill patients.
To evaluate platelet function in patients undergoing continuous pump-driven veno-venous hemofiltration. ⋯ Continuous pump-driven veno-venous hemofiltration significantly changed platelet aggregability, which became obvious 2 to 3 days after the start of hemofiltration.