Critical care medicine
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Critical care medicine · Mar 1997
Experimental study of double-lumen, two-stage endotracheal tube during conventional mechanical ventilation in rabbits.
To evaluate the effects of a double-lumen, two-stage endotracheal tube on gas exchanges (ventilatory efficiency) during conventional mechanical ventilation, using a ventilator in rabbits. ⋯ Compared with the conventional endotracheal tube, the new double-lumen, two-stage endotracheal tube reduced Paco2 by decreasing anatomical deadspace in rabbits with normal and injured lungs under pressure control ventilation, thus enhancing ventilatory efficiency and reducing ventilator-induced injury.
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Critical care medicine · Mar 1997
Comparative StudyContinuous assessment of gastric intramucosal PCO2 and pH in hemorrhagic shock using capnometric recirculating gas tonometry.
To test a novel device for continuous monitoring of gut intramucosal PCO2 and pH and to compare its use with conventional intermittent saline balloon-tonometry in a model of hemorrhagic shock. ⋯ Capnometric recirculating gas tonometry allows continuous and automated assessment of gastrointestinal tract perfusion by providing on-line measurements of intramucosal PCO2, which can also be used to derive intramucosal pH. The technique is able to detect changes in intramucosal PCO2 in response to an induced insult over intervals as short as 5 mins.
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Critical care medicine · Mar 1997
Comment Letter Comparative StudyProlonged sedation with midazolam or propofol.
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Critical care medicine · Mar 1997
L-canavanine, an inhibitor of inducible nitric oxide synthase, improves venous return in endotoxemic rats.
To investigate the hemodynamic effects of L-canavanine (an inhibitor of inducible, but not of constitutive, nitric oxide synthase) in endotoxic shock. ⋯ Six hours after an endotoxin challenge in rats, low cardiac output develops, which appears to be primarily related to relative hypovolemia. L-canavanine, a selective inhibitor of the inducible nitric oxide synthase, increases the mean systemic filling pressure, thereby improving venous return, under these conditions.
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Critical care medicine · Mar 1997
Dose-response relationship between aortic infusions of polymerized bovine hemoglobin and return of circulation in a canine model of ventricular fibrillation and advanced cardiac life support.
Return of spontaneous circulation after cardiac arrest may be a function of vital organ perfusion. Selective aortic perfusion and oxygenation with oxygenated ultrapurified polymerized bovine hemoglobin improves vital organ perfusion and is an effective adjunct in the treatment of cardiac arrest. This study determined the dose-response relationship between intra-aortic oxygenated ultrapurified polymerized bovine hemoglobin and return of spontaneous circulation. ⋯ There is a dose-response relationship between the volume of oxygenated ultrapurified polymerized bovine hemoglobin administered by selective aortic perfusion and oxygenation and return of spontaneous circulation after prolonged cardiac arrest. This result supports the hypothesis that vital organ flow is causally related to improved outcome.