Critical care medicine
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Critical care medicine · Jan 2006
Editorial Comment Comparative StudyLinking gut-associated lymphoid tissue to multiple organ dysfunction syndrome and infection.
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Critical care medicine · Jan 2006
Editorial Comment Comparative StudyThe Holy Grail of volume resuscitation in the septic patient is...
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Critical care medicine · Jan 2006
Editorial Comment Comparative StudyPhosphoinositide-3-kinase gamma: is it really pivotal for ventilator-induced lung injury?
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Critical care medicine · Jan 2006
Randomized Controlled Trial Multicenter Study Comparative Study Historical ArticleEffect of low doses of corticosteroids in septic shock patients with or without early acute respiratory distress syndrome.
We investigated the efficacy of low doses of corticosteroids in septic shock patients with or without early acute respiratory distress syndrome (ARDS) by post hoc analysis of a previously completed clinical trial. ⋯ This post hoc analysis shows that a 7-day treatment with low doses of corticosteroids was associated with better outcomes in septic shock-associated early ARDS nonresponders, but not in responders and not in septic shock patients without ARDS.
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Critical care medicine · Jan 2006
Randomized Controlled Trial Multicenter Study Comparative StudyHypercapnic acidosis and mortality in acute lung injury.
We tested the hypothesis that hypercapnic acidosis is associated with reduced mortality rate in patients with acute lung injury independent of changes in mechanical ventilation. ⋯ Hypercapnic acidosis was associated with reduced 28-day mortality in the 12 mL/kg predicted body weight tidal volume group after controlling for comorbidities and severity of lung injury. These results are consistent with a protective effect of hypercapnic acidosis against ventilator-associated lung injury that was not found when the further ongoing injury was reduced by 6 mL/kg predicted body weight tidal volumes.