Critical care medicine
-
Critical care medicine · Jan 2010
Comparative StudyDistant effects of nitric oxide inhalation in endotoxemic pigs.
Inhalation of nitric oxide (INO) has distant effects. By a blood- borne factor, INO down-regulates endogenous nitric oxide production in healthy pig lungs, resulting in vasoconstriction in lung regions not directly reached by INO. The aim of this study was to investigate whether INO has distant effects in endotoxemic pig lungs. The hypothesis was that INO down-regulates endogenous NO production in lung regions not reached by INO. ⋯ As opposed to findings in healthy pigs, INO in endotoxemic pigs causes an increase in endogenous NO production in lung regions not reached by INO. Increased NO production in nonventilated lung regions may cause vasodilatation, counteracting the INO-induced increase in blood flow to the ventilated lung regions.
-
Critical care medicine · Jan 2010
Comment Letter Comparative StudyAcute lung injury in children: importance of host factors.
-
Critical care medicine · Jan 2010
Comment Letter Comparative StudySuperiority of levosimendan over dobutamine in right ventricle failure.
-
Critical care medicine · Jan 2010
Comment Letter Comparative StudyCorticosteroids and the original vasopressin and septic shock trial subgroups.