Critical care medicine
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Critical care medicine · Jan 2011
Editorial Comment Comparative StudyPediatric patients with out-of hospital cardiac arrest: Is therapeutic hypothermia for them?
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Critical care medicine · Jan 2011
Daptomycin pharmacokinetics in critically ill patients receiving continuous venovenous hemodialysis.
To investigate daptomycin pharmacokinetics in critically ill patients receiving continuous venovenous hemodialysis to develop dosing recommendations. ⋯ Daptomycin at 8 mg/kg every 48 hrs in critically ill patients receiving continuous venovenous hemodialysis resulted in good drug exposure, achieved high peak concentrations to maximize daptomycin's concentration-dependent activity, and resulted in trough concentration that would minimize the risk of myopathy. CLINICALTRIALS.GOV IDENTIFIER: NCT00663403.