Critical care medicine
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Critical care medicine · Sep 2011
Morphologic and functional renal impact of acute kidney injury after prolonged hemorrhagic shock in mice.
Sparse data are available on renal consequences of hemorrhagic shock in mice. This study aimed to extend the current knowledge on functional and morphologic renal impact of hemorrhagic shock in mice and to determine its ability to stand as an accurate model of acute kidney injury. ⋯ Our data indicate that apparent recovery of renal function after acute kidney injury can mask persisting dysfunctions and tissular damages that could predispose to chronic kidney disease. Prolonged hemorrhagic shock in mice closely mimics renal effects induced by similar situation in humans, thus providing a useful tool to investigate pathophysiological mechanisms and protection strategies against acute kidney injury in situations such as hemorrhagic shock.
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Critical care medicine · Sep 2011
Editorial CommentBurn fluid resuscitation: let the autopilot do it!