Critical care medicine
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Critical care medicine · Feb 2012
Editorial CommentCarbon monoxide and outcome of stroke--a dream CORM true?.
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Critical care medicine · Feb 2012
Comparative StudyMechanical stress induces lung fibrosis by epithelial-mesenchymal transition.
Many mechanically ventilated patients with acute respiratory distress syndrome develop pulmonary fibrosis. Stresses induced by mechanical ventilation may explain the development of fibrosis by a number of mechanisms (e.g., damage the alveolar epithelium, biotrauma). The objective of this study was t test the hypothesis that mechanical ventilation plays an important role in the pathogenesis of lung fibrosis. ⋯ Mechanical stress induces lung fibrosis, and epithelia-mesenchymal transition may play an important role in mediating the ventilator-induced lung fibrosis.
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Critical care medicine · Feb 2012
Comparative StudyBenefits of ethyl gallate versus norepinephrine in the treatment of cardiovascular collapse in Pseudomonas aeruginosa septic shock in dogs.
Vasopressor therapy is required in septic shock to maintain tissue perfusion in the face of hypotension. Unfortunately, there are significant side effects of current vasopressors, and newer agents need to be developed. We recently discovered that ethyl gallate, a nonflavonoid phenolic antioxidant found in food substances, could reverse low mean arterial pressure found in an experimental model of septic shock due to inhibition of hydrogen peroxide signaling. In the present study, we compared the hemodynamic and biochemical effects of ethyl gallate vs. those of the commonly used vasopressor, norepinephrine, in a bacteremic canine model of Pseudomonas aeruginosa sepsis in two protocols. ⋯ These results suggest that phenolic antioxidants, such as ethyl gallate, that inhibit hydrogen peroxide signaling, may represent an alternative class of vasopressors for use in septic shock.
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Critical care medicine · Feb 2012
Editorial CommentStatins as neuroprotectants after subarachnoid hemorrhage.
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Critical care medicine · Feb 2012
Editorial CommentThe big chill: cooling sickle cells with caution.