Critical care medicine
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Critical care medicine · Oct 2014
Recombinant Human Erythropoietin Pretreatment Attenuates Acute Renal Tubular Injury Against Ischemia-Reperfusion by Restoring Transient Receptor Potential Channel-6 Expression and Function in Collecting Ducts.
Acute renal tubular injury is a serious complication in the postoperative period, which is associated with high mortality and increased ICU stay. We aimed to demonstrate the protective effect of rhEPO against acute tubular injury induced by ischemia-reperfusion and to explore the mechanism of canonical transient receptor potential channel-6. ⋯ Recombinant human erythropoietin pretreatment at the dose of 5,000 IU/kg potently prevented ischemia-reperfusion-induced acute tubular injury, which might be partly attributed to the restoring the effect of transient receptor potential channel-6 expression and collecting duct function.