Critical care medicine
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Critical care medicine · Dec 2014
DNAX-Activating Protein of 12 kDa Impairs Host Defense in Pneumococcal Pneumonia.
Streptococcus pneumoniae is the most common causative organism in community-acquired pneumonia responsible for millions of deaths every year. DNAX-activating protein of 12 kDa is an adaptor molecule for different myeloid expressed receptors involved in innate immunity. ⋯ These data suggest that DNAX-activating protein of 12 kDa impairs host defense during pneumococcal pneumonia at the primary site of infection at least in part by inhibiting phagocytosis by alveolar macrophages.