Critical care medicine

• Latest
• Best
• Search…

• Critical care medicine · Jan 2014

  Melatonin Receptors Mediate Improvements of Survival in a Model of Polymicrobial Sepsis.

  Melatonin has been demonstrated to improve survival after experimental sepsis via antioxidant effects. Yet, recent evidence suggests that this protective capacity may also rely on melatonin receptor activation. Therefore, the present study was designed to investigate whether selective melatonin receptor-agonist ramelteon may influence survival and immune response in a model of polymicrobial sepsis in rats, wild-type and melatonin receptor MT1/MT2 double knockout mice. ⋯ Melatonin receptors mediate improvements of survival after polymicrobial sepsis in rats and mice; this effect appears to be independent from major alterations of cytokine release.

  keep going… mark as read…

• Critical care medicine · Jan 2014

  Comment Letter

  The "obesity-mortality paradox" phenomenon in critically ill patients: one size does not fit all.

  no abstract available

  read on… or not…

• Critical care medicine · Jan 2014

  Comment Letter

  Association of body mass index with hospital mortality in ICU patients.

  no abstract available

  read more… or not…

• Critical care medicine · Jan 2014

  Editorial Comment

  The Role of Multivessel Coronary Intervention in ST-Segment Elevation Myocardial Infarction Complicated by Cardiogenic Shock: Have We Reached a Verdict?*.

  no abstract available

  explore further… or not…

• Critical care medicine · Jan 2014

  Comment Letter

  Does cecal ligation and puncture-induced murine sepsis cause lung injury or not?

  no abstract available

  read more… or not…