Critical care medicine
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Critical care medicine · Jul 2014
Early Administration of Hydrocortisone Replacement After the Advent of Septic Shock: Impact on Survival and Immune Response.
To investigate the impact of early initiation of hydrocortisone therapy on the clinical course of septic shock and on cytokine release. ⋯ In patients receiving hydrocortisone for septic shock, early initiation of treatment was associated with improved survival. This treatment was also associated with attenuated stimulation of tumor necrosis factor-α.
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Critical care medicine · Jul 2014
Effects of Bone Marrow-Derived Mononuclear Cells From Healthy or Acute Respiratory Distress Syndrome Donors on Recipient Lung-Injured Mice.
The advantage of using autologous bone marrow-derived mononuclear cells to treat acute respiratory distress syndrome patients is to prevent immunological rejection. However, bone marrow-derived mononuclear cells may be altered by different acute respiratory distress syndrome etiologies, resulting in questionable efficacy and thus limited clinical application. We aimed to investigate the effects of bone marrow-derived mononuclear cells obtained from healthy and acute respiratory distress syndrome donors on pulmonary and extrapulmonary acute respiratory distress syndrome. ⋯ Bone marrow-derived mononuclear cells from ARDSp and ARDSexp donors showed different characteristics but were as effective as cells obtained from healthy donors in reducing inflammation and remodeling, suggesting the utility of autologous transplant of bone marrow-derived mononuclear cells in the clinical setting.
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Critical care medicine · Jul 2014
Editorial CommentSurvival for the cirrhotic patient with septic shock*.