Critical care medicine
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Critical care medicine · May 2017
Review Meta AnalysisAntipyretic Therapy in Critically Ill Septic Patients: A Systematic Review and Meta-Analysis.
This meta-analysis aimed to examine the impact of antipyretic therapy on mortality in critically ill septic adults. ⋯ Antipyretic treatment does not significantly improve 28-day/hospital mortality in adult patients with sepsis.
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Critical care medicine · May 2017
Randomized Controlled Trial Multicenter StudyMortality Risk Stratification After Traumatic Brain Injury and Hazard of Death With Titrated Hypothermia in the Eurotherm3235Trial.
Hypothermia reduces intracranial hypertension in patients with traumatic brain injury but was associated with harm in the Eurotherm3235Trial. We stratified trial patients by International Mission for Prognosis and Analysis of Clinical Trials in [Traumatic Brain Injury] (IMPACT) extended model sum scores to determine where the balance of risks lay with the intervention. ⋯ Hypothermia as a first line measure to reduce intracranial pressure to less than 20 mm Hg is harmful in patients with a lower severity of injury and no clear benefit exists in patients with more severe injuries.
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Critical care medicine · May 2017
Multicenter Study Observational StudyAn Unbalanced Inflammatory Cytokine Response Is Not Associated With Mortality Following Sepsis: A Prospective Cohort Study.
The prevailing theory of host response during sepsis states that an excessive production of pro-inflammatory mediators causes early deaths, whereas a predominantly anti-inflammatory response may lead to immunosuppression, secondary infection, and late deaths. We assessed inflammatory (im)balance by measuring pro-inflammatory interleukin-6 and anti-inflammatory interleukin-10 during three distinct time periods after sepsis, and assessed its association with mortality. ⋯ Although both interleukin-6 and interleukin-10 productions are associated with death, the balance of these inflammatory mediators does not seem to impact either early, intermediate, or late mortality in patients presenting to the ICU with sepsis.