Critical care medicine
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Critical care medicine · Apr 2019
Observational StudyLipidomics Detection of Brain Cardiolipins in Plasma Is Associated With Outcome After Cardiac Arrest.
Brain mitochondrial dysfunction limits neurologic recovery after cardiac arrest. Brain polyunsaturated cardiolipins, mitochondria-unique and functionally essential phospholipids, have unprecedented diversification. Since brain cardiolipins are not present in plasma normally, we hypothesized their appearance would correlate with brain injury severity early after cardiac arrest and return of spontaneous circulation. ⋯ Brain-specific cardiolipins accumulate in plasma early after return of spontaneous circulation and proportional to neurologic injury representing a promising novel biomarker.
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Critical care medicine · Apr 2019
Editorial CommentPredicting Fluid Responsiveness: Time for Automation.