Critical care medicine
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Critical care medicine · Aug 2023
Meta AnalysisThe Efficacy of Glutamine Supplementation in Severe Adult Burn Patients: A Systematic Review With Trial Sequential Meta-Analysis.
Evidence supporting glutamine supplementation in severe adult burn patients has created a state of uncertainty due to the variability in the treatment effect reported across small and large randomized controlled trials (RCTs). We aimed to systematically review the effect of glutamine supplementation on mortality in severe adult burn patients. ⋯ Glutamine supplementation, regardless of administration, does not appear to improve clinical outcomes in severely adult burned patients.