Critical care medicine
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Critical care medicine · Dec 2024
ReviewAngiotensin-II and Thromboembolic Events: A Systematic Review.
To evaluate and synthesize the existing evidence for the association of angiotensin-II with thromboembolic events. ⋯ Published evidence does not currently support or refute an association between angiotensin-II and an increased risk of venous or arterial thromboembolic events. Given the limited quality of available data, future studies should explicitly define diagnostic and reporting criteria for such events.
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Critical care medicine · Dec 2024
Multicenter StudyEpidemiology, Process of Care, and Associated Outcomes of Pediatric Out-of-Hospital Cardiac Arrest in China: Results From a Prospective, Multicenter, Population-Based Registry.
To comprehensively describe the incidence, process of care, outcomes, and variation among different age groups of pediatric out-of-hospital cardiac arrest (OHCA) in China. ⋯ This study provides the first national exploration of pediatric OHCA in China. The high proportion of nonmedical causes underscores the importance of preventing accidents in children. Gaps in the chain of survival and patient outcomes provide a focus for improving the treatment of pediatric OHCA in China and other developing countries.
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Critical care medicine · Dec 2024
Adjudication of Codes for Identifying Sepsis in Hospital Administrative Data by Expert Consensus.
Refine the administrative data definition of sepsis in hospitalized patients, including less severe cases. ⋯ Compared with other code-based algorithms, AlgorithmL includes more infection and organ dysfunction codes. AlgorithmL incidence rates are higher; hospital mortality rates are lower. AlgorithmL may more fully encompass the full range of sepsis severity.
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Critical care medicine · Dec 2024
Doctors as Device Manufacturers? Regulation of Clinician-Generated Innovation in the ICU.
Critical care physicians are rich sources of innovation, developing new diagnostic, prognostic, and treatment tools they deploy in clinical practice, including novel software-based tools. Many of these tools are validated and promise to actively help patients, but physicians may be unlikely to distribute, implement, or share them with other centers noncommercially because of unsettled ethical, regulatory, or medicolegal concerns. This Viewpoint explores the potential barriers and risks critical care physicians face in disseminating device-related innovations for noncommercial purposes and proposes a framework for risk-based evaluation to foster clear pathways to safeguard equitable patient access and responsible implementation of clinician-generated technological innovations in critical care.