Critical care medicine
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Critical care medicine · Sep 1995
A liquid perfluorochemical decreases the in vitro production of reactive oxygen species by alveolar macrophages.
To determine whether reactive oxygen metabolite production by alveolar macrophages is affected by liquid perfluorochemical exposure. ⋯ Exposure of alveolar macrophages to perfluorooctylbromide in vitro decreases the responsiveness of macrophages to potent stimuli. This finding may partially explain the decrease in pulmonary inflammation seen in animals treated with partial liquid ventilation during experimentally induced lung injury.
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Critical care medicine · Sep 1995
Association of myocardial ischemia with failure to wean from mechanical ventilation.
To determine if myocardial ischemia, as detected by continuous electrocardiographic monitoring, is correlated with continued ventilator dependence in patients who have had difficulties weaning from mechanical ventilation. ⋯ Myocardial ischemia (as detected by a 24-hr, continuous Holter monitor) occurs frequently in ventilator-dependent patients. The occurrence of ischemia was associated with failure to wean from mechanical ventilation in this patient population.
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To determine the pharmacokinetics of intravenous phenytoin in critically ill infants and children with acute neurologic injury. ⋯ Based on the average Km and Vmax values of the children enrolled in our study, it appears that children with neurologic injury between the ages of 0.5 and 9 yrs may require dosages of at least 8 to 10 mg/kg/day, and children aged 10 to 16 yrs may require 6 to 8 mg/kg/day to attain therapeutic phenytoin concentrations.
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Critical care medicine · Aug 1995
Multicenter Study Comparative StudyA comparison of intensive care unit utilization in Alberta and western Massachusetts.
To analyze differences in intensive care unit (ICU) utilization between a Canadian province and a U.S. area. ⋯ Western Massachusetts hospitalized patients are more likely to be treated in an ICU than are similar patients in Alberta. There is no evidence that the greater ICU utilization in western Massachusetts led to a lower hospital mortality rate.