Critical care medicine
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Critical care medicine · Jan 1994
Randomized Controlled Trial Multicenter Study Clinical TrialInitial evaluation of human recombinant interleukin-1 receptor antagonist in the treatment of sepsis syndrome: a randomized, open-label, placebo-controlled multicenter trial.
To evaluate the safety, pharmacokinetics, and efficacy of human recombinant interleukin-1 receptor antagonist (IL-1ra) in the treatment of patients with sepsis syndrome. ⋯ This initial evaluation suggests that human recombinant IL-1ra is safe and may provide a dose-related survival advantage to patients with sepsis syndrome. A larger, definitive clinical trial is needed to confirm these findings.
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Critical care medicine · Jan 1994
Optimal sedation of mechanically ventilated pediatric critical care patients.
To derive a target range of optimal sedation for the COMFORT Scale and to prospectively test that target range against intensivist assessment of adequacy of sedation. ⋯ Adequacy of sedation is measured more consistently by observers using the COMFORT Scale than by intensivist global assessment.
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Critical care medicine · Jan 1994
Comparative StudyDopamine infusion during resuscitation of experimental hemorrhagic shock.
To compare the effects of starting dopamine administration early or late on organ perfusion by measuring tissue oxygen tensions during standard volume resuscitation of hemorrhagic shock. ⋯ Starting dopamine administration early during volume resuscitation in a model of experimental hemorrhagic shock led to higher liver, subcutaneous, and transcutaneous tissue oxygen levels. This finding indicates enhanced tissue oxygen perfusion, especially in the liver.
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Critical care medicine · Jan 1994
Quantitative effects of low-dose dopamine on urine output in oliguric surgical intensive care unit patients.
To quantify the magnitude and time course of the effect of low-dose dopamine (2.5 micrograms/kg/min) infusions on urine output in oliguric patients. ⋯ Low-dose dopamine infusion alone produces a drug-dependent increase in urine output in oliguric, euvolemic ICU patients. Maximal effect is temporally variable.