Journal of the American Academy of Child and Adolescent Psychiatry
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J Am Acad Child Adolesc Psychiatry · Feb 2002
Clinical predictors of posttraumatic stress disorder after closed head injury in children.
To describe injury, demographic, and neuropsychiatric characteristics of children who develop posttraumatic stress disorder (PTSD) and posttraumatic stress symptoms (PTSS) after closed head injury (CHI). ⋯ PTSD developed in 13% of children with severe CHI accompanied by traumatic amnesia. Predictors of PTSD and PTSS after CHI, according to parent and child report, are consistent with predictors of PTSD and PTSS that develop after non-head injury trauma.
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J Am Acad Child Adolesc Psychiatry · Aug 2001
Relationship between acute morphine and the course of PTSD in children with burns.
To investigate the relationship between the dose of morphine administered during a child's hospitalization for an acute burn and the course of posttraumatic stress disorder (PTSD) symptoms over the 6-month period following discharge from the hospital. ⋯ This study suggests the possibility that acute treatment with morphine can secondarily prevent PTSD. This result is discussed in terms of the possible effect of morphine on fear conditioning and the consolidation of traumatic memory.
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J Am Acad Child Adolesc Psychiatry · Jul 2001
Randomized Controlled Trial Multicenter Study Comparative Study Clinical TrialEfficacy of paroxetine in the treatment of adolescent major depression: a randomized, controlled trial.
To compare paroxetine with placebo and imipramine with placebo for the treatment of adolescent depression. ⋯ Paroxetine is generally well tolerated and effective for major depression in adolescents.
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J Am Acad Child Adolesc Psychiatry · Jun 2001
Randomized Controlled Trial Multicenter Study Clinical TrialDouble-blind, placebo-controlled study of amantadine hydrochloride in the treatment of children with autistic disorder.
To test the hypothesis that amantadine hydrochloride is a safe and effective treatment for behavioral disturbances--for example, hyperactivity and irritability--in children with autism. ⋯ Parents did not report statistically significant behavioral change with amantadine. However, clinician-rated improvements in behavioral ratings following treatment with amantadine suggest that further studies with this or other drugs acting on the glutamatergic system are warranted. The design of these and similar drug trials in children with autistic disorder must take into account the possibility of a large placebo response.