American journal of preventive medicine
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Few investigations have examined whether associations between the apolipoprotein E genotype (apo E) and total cholesterol or LDL-C are modified or explained by other characteristics. The objective of this study was to explore effects of behavioral characteristics, physical growth, body composition, sexual maturation, and endocrine function on age trajectories of total cholesterol and LDL-C by apo E in adolescent girls. ⋯ Adolescent girls with epsilon3/3 and epsilon3/4 genotypes had higher total cholesterol and LDL-C and showed different patterns of change, compared to those with epsilon2/3 genotype. These apo E effects were independent of behavioral characteristics, physical growth, body composition, sexual maturation, and endocrine function. Girls with epsilon3/3 or epsilon3/4 genotypes may be at risk for elevated total cholesterol and LDL-C later in life.
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Longitudinal data on the normal development of blood lipids and its relationships with body fatness in children and adolescents are limited. Objectives of the current analysis were to estimate trajectories related to age for four blood lipid components and to examine the impact of change in body fatness on blood lipid levels, comparing estimated effects among adiposity indices, in children and adolescents. ⋯ Patterns of change with age in blood lipid components vary significantly among gender and racial groups. Increase in body fatness among children is consistently associated with adverse change in blood lipids. Evaluation of blood lipid level should take into account variation by age, gender, and race. Intervention through body-fat control should help prevent adverse lipid levels in children and adolescents.
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Parental obesity and TV viewing are risk factors for childhood obesity. This study assessed the association of children's TV viewing and computer use with body mass and examined whether parental weight status modified the association. ⋯ These study findings are consistent with a genetic contribution of parental weight; however, overweight/obese parents may also exhibit behavior patterns that negatively influence children's TV viewing and have an impact on child overweight status. The effect of parental BMI on children's BMI may have both a genetic and an environmental linkage.
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Most research regarding the perpetration of occupational homicide has focused on robbery-related violence; relatively little is known about the circumstances surrounding non-robbery-related occupational homicides and interventions that may prevent these events. A case series was assembled and utilized to examine occupational homicides that were and were not motivated by robbery to determine if select characteristics of the events differed according to the perpetrator's motivation for the crime and relationship to the workplace. ⋯ Non-robbery-related homicides constitute a meaningful proportion of occupational homicides, and the characteristics of these cases can differ from those that are robbery-related. The current system by which workplace homicides are classified could be expanded to include robbery motivation. Efforts to examine occupational-homicide-prevention strategies for non-robbery-related homicides are important.
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The American Academy of Pediatrics (AAP) criterion for screening for hypercholesterolemia in children is family history of hypercholesterolemia or cardiovascular disease or BMI > or =85th percentile. This paper aims to determine the sensitivity, specificity, and positive predictive value (PPV) of dyslipidemia screening using AAP criteria along with either family history or BMI. ⋯ When the BMI screening criterion was used along with the family history criterion, sensitivity increased, specificity decreased, and PPV changed trivially for detection of dyslipidemia. Despite increased screening sensitivity by adding the BMI criterion, a clinically significant number of children still may be misclassified.